a research program was conducted on different clay-bearing rocks selected from the ilam, sarpol-e zahab and tajarak regions (iran) to predict their slaking characteristics. the new durability apparatus (nested mesh drums) separates disintegrated particles varying from > 25.4 to < 2 mm as the drums were rotated. on the basis of the particle size distribution, the disintegration ratio (dr) was us...

Stavudine oral disintegration tablets were formulated to minimize the bitter taste and to reduce the first-pass hepatic metabolism. The various precompression parameters like the angle of repose, bulk density, compressibility index and Hausner's ratio were determined for the powder blend. In this study, 14 formulations of stavudine oral disintegration tablet were prepared by direct compression ...

o-stars in photographic plates are classified into those originated from heavy and light nuclei. The branching ratio of disintegration modes, the a-j ratio, and the energy distribution of emitted particles are measured for light stars. Foilowing characteristic features of light stars are ascertained; 1) the large prong number, 2) the large a-p ratio, 3) the low kinetic energy of emitted particl...

The present investigation deals with the formulation of taste masked fast disintegrating tablets of Ciprofloxacin that disintegrate in the oral cavity upon contact with saliva and thereby improve therapeutic efficacy. Ciprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. It is a second-generation fluoroquinolone antibacterial that kills bacteria by interfer...

Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as Agar, gum karaya, platago ovata on disintegration time was studied. T...

Tablets with 250 mg of Rhodiola rosea L. extract disintegrating in less than 10 min were developed. The influence of the extract content and type of fillers and disintegrants on disintegration time and tablet hardness was evaluated. Type of the filler and the extract/filler ratio but not the type of disintegrant determined fast disintegration of the tablets. It was demonstrated that the extract...

A research program was conducted on different clay-bearing rocks selected from the Ilam, Sarpol-e Zahab and Tajarak regions (Iran) to predict their slaking characteristics. The new durability apparatus (nested mesh drums) separates disintegrated particles varying from > 25.4 to < 2 mm as the drums were rotated. On the basis of the particle size distribution, the disintegration ratio (DR) was us...

The mechanisms of disintegration of submicrometer particles irradiated by short laser pulses are studied by a molecular dynamics simulation technique. Simulations at different laser fluences are performed for particles with homogeneous composition and particles with transparent inclusions. Spatially nonuniform deposition of laser energy is found to play a major role in defining the character an...

Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcryst...

The mechanical and disintegration properties of paracetamol tablets formulated using Delonix regia seed gum (DRSG) as a binder have been studied in this work. Acacia BP (ACG) and tragacanth BP (TRG) were used as official gum standards. The mechanical properties, i.e. tensile strength (TS) and brittle fracture index (BFI), showed that with an increase in concentration of the gum binder, the tens...